Abstract | OBJECTIVE: METHODS: We assessed the EVD infection rate in patients receiving intraventricular alteplase over a 12-month period. Patients were divided into intraventricular alteplase and non-intraventricular alteplase groups; ventriculitis rates were compared. RESULTS: EVDs were placed in 93 patients. Six of 7 (86%) patients who received intraventricular alteplase developed ventriculitis versus 4 of 86 (5%) patients in the non-intraventricular alteplase group (p<0.0001). CONCLUSION: Intraventricular alteplase use may increase ventriculitis risk. Currently, we reserve intraventricular alteplase for patients with EVDs obstructed by hematoma accompanied by increased intracranial pressure.
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Authors | Andrew J Fabiano, Thomas J Gruber, Melissa S Baxter |
Journal | Clinical neurology and neurosurgery
(Clin Neurol Neurosurg)
Vol. 115
Issue 11
Pg. 2362-4
(Nov 2013)
ISSN: 1872-6968 [Electronic] Netherlands |
PMID | 24034819
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Tissue Plasminogen Activator
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Topics |
- Cerebral Hemorrhage
(drug therapy, surgery)
- Female
- Humans
- Hydrocephalus
(drug therapy, surgery)
- Male
- Surgical Wound Infection
(etiology)
- Thrombolytic Therapy
(adverse effects, methods)
- Tissue Plasminogen Activator
(therapeutic use)
- Treatment Outcome
- Ventriculostomy
(adverse effects, methods)
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