The effect of a dentifrice containing Magnolia extract on established plaque and gingivitis in man: a six-month clinical study.

The aim was to evaluate the clinical effect of a dentifrice containing 0.3% Magnolia extract on dental plaque and gingivitis.
The trial was a 6-month double-blind, stratified, randomized and 2-armed parallel group study. Forty-six subjects in the test group brushed their teeth with a dentifrice containing 0.3% Magnolia extract and 48 subjects in the control group brushed with a placebo dentifrice. Plaque and gingivitis were assessed at baseline, 3 and 6 months.
There was a significantly larger gingivitis reduction in the Magnolia group than in the control group (0.26 ± 0.11 versus 0.11 ± 0.12) (P < 0.001). There was a greater increase in the total number of healthy gingival units Gingival Index (GI score 0) in the Magnolia group than in the control group (149% versus 31%) and a larger reduction in inflamed gingival units (GI score 2/3) (60% versus 30%). Furthermore, at sites with similar amounts of plaque, less clinical signs of gingival inflammation were observed in the Magnolia group than in the control group.
Six months' unsupervised use of a dentifrice containing 0.3% Magnolia extract resulted in significantly greater gingivitis reduction than a corresponding control dentifrice.
AuthorsM-K Hellström, P Ramberg
JournalInternational journal of dental hygiene (Int J Dent Hyg) Vol. 12 Issue 2 Pg. 96-102 (May 2014) ISSN: 1601-5037 [Electronic] England
PMID24034670 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Copyright© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Chemical References
  • Cariostatic Agents
  • Dentifrices
  • Placebos
  • Plant Extracts
  • Sodium Fluoride
  • Adult
  • Aged
  • Cariostatic Agents (therapeutic use)
  • Dental Plaque (prevention & control)
  • Dental Plaque Index
  • Dentifrices (therapeutic use)
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Gingivitis (prevention & control)
  • Humans
  • Magnolia
  • Male
  • Middle Aged
  • Periodontal Index
  • Phytotherapy (methods)
  • Placebos
  • Plant Extracts (therapeutic use)
  • Sodium Fluoride (therapeutic use)
  • Toothbrushing (instrumentation)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: