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Epstein-Barr virus-associated smooth muscle tumors in a composite tissue allograft and a pediatric liver transplant recipient.

Abstract
Epstein-Barr virus (EBV) is known to establish latent infections in B-lymphocytes that can cause lymphoproliferative disorders particularly in immunocompromised patients. More recently, the development of rare EBV-associated smooth muscle tumors has been reported in transplant recipients. We herein describe 2 new cases of EBV-associated post-transplant smooth muscle tumors (EBV-PTSMT), including the first in a facial composite tissue graft recipient. Among the striking features shared by these 2 patients were their young ages, the fact that they were naïve for EBV before the transplantation, that they developed a post-transplant lymphoproliferative disorder before the diagnosis of EBV-PTSMT, and that they responded favorably to reduction of immunosuppression. Radiological and histologic features of EBV-PTSMT are shown. Finally, pathophysiology and therapeutic management of EBV-PTSMT are discussed based on a comprehensive review of the literature.
AuthorsA Conrad, A-S Brunet, V Hervieu, C Chauvet, F Buron, S Collardeau-Frachon, C Rivet, P Cassier, S Testelin, A Lachaux, E Morelon, O Thaunat
JournalTransplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 15 Issue 5 Pg. E182-6 (Oct 2013) ISSN: 1399-3062 [Electronic] Denmark
PMID24034213 (Publication Type: Case Reports, Journal Article, Review)
Copyright© 2013 John Wiley & Sons A/S.
Topics
  • Adult
  • Allografts
  • Epstein-Barr Virus Infections (diagnosis, etiology, therapy, virology)
  • Facial Transplantation (adverse effects)
  • Female
  • Herpesvirus 4, Human (genetics, immunology, isolation & purification)
  • Humans
  • Immunocompromised Host
  • Immunosuppression (adverse effects)
  • Infant
  • Liver Transplantation (adverse effects)
  • Lymphoma, B-Cell (diagnosis, etiology, therapy)
  • Male
  • Postoperative Complications (diagnosis, etiology, therapy)
  • Smooth Muscle Tumor (diagnosis, etiology, therapy, virology)

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