Abstract |
Epstein-Barr virus (EBV) is known to establish latent infections in B-lymphocytes that can cause lymphoproliferative disorders particularly in immunocompromised patients. More recently, the development of rare EBV-associated smooth muscle tumors has been reported in transplant recipients. We herein describe 2 new cases of EBV-associated post-transplant smooth muscle tumors (EBV-PTSMT), including the first in a facial composite tissue graft recipient. Among the striking features shared by these 2 patients were their young ages, the fact that they were naïve for EBV before the transplantation, that they developed a post-transplant lymphoproliferative disorder before the diagnosis of EBV-PTSMT, and that they responded favorably to reduction of immunosuppression. Radiological and histologic features of EBV-PTSMT are shown. Finally, pathophysiology and therapeutic management of EBV-PTSMT are discussed based on a comprehensive review of the literature.
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Authors | A Conrad, A-S Brunet, V Hervieu, C Chauvet, F Buron, S Collardeau-Frachon, C Rivet, P Cassier, S Testelin, A Lachaux, E Morelon, O Thaunat |
Journal | Transplant infectious disease : an official journal of the Transplantation Society
(Transpl Infect Dis)
Vol. 15
Issue 5
Pg. E182-6
(Oct 2013)
ISSN: 1399-3062 [Electronic] Denmark |
PMID | 24034213
(Publication Type: Case Reports, Journal Article, Review)
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Copyright | © 2013 John Wiley & Sons A/S. |
Topics |
- Adult
- Allografts
- Epstein-Barr Virus Infections
(diagnosis, etiology, therapy, virology)
- Facial Transplantation
(adverse effects)
- Female
- Herpesvirus 4, Human
(genetics, immunology, isolation & purification)
- Humans
- Immunocompromised Host
- Immunosuppression Therapy
(adverse effects)
- Infant
- Liver Transplantation
(adverse effects)
- Lymphoma, B-Cell
(diagnosis, etiology, therapy)
- Male
- Postoperative Complications
(diagnosis, etiology, therapy)
- Smooth Muscle Tumor
(diagnosis, etiology, therapy, virology)
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