Grb14 as an independent good prognosis factor for breast cancer patients treated with neoadjuvant chemotherapy.

Abstract

OBJECTIVE:

Growth factor receptor-binding protein 14, a new member of noncatalytic adaptor proteins family, has been shown to be upregulated in breast cancer. We investigated the prognostic value of growth factor receptor-binding protein 14 expression in breast cancer patients treated with neoadjuvant chemotherapy.

METHODS:

Primary breast cancer specimens were taken from locally advanced breast cancer patients in a Phase II clinical trial of neoadjuvant chemotherapy and the expression pattern of growth factor receptor-binding protein 14 was determined by immunohistochemistry. Kaplan-Meier analysis and Cox regression model were used to assess disease-free and overall survival, according to the expression of growth factor receptor-binding protein 14 in tumor cells.

RESULTS:

Our result showed that growth factor receptor-binding protein 14 was highly expressed in 23.1% of breast cancer sections, and high expression of growth factor receptor-binding protein 14 was significantly associated with better disease-free (P = 0.016, hazard ratio 0.07, 95% confidence interval 0.06-0.08) and overall survival (P = 0.004, hazard ratio 0.02, 95% confidence interval 0.02-0.03), compared with the low-expression group. Multivariate analysis indicated that high expression of growth factor receptor-binding protein 14 was an independent good prognostic factor for both disease-free (P = 0.04, hazard ratio 0.37, 95% confidence interval 0.14-0.98) and overall survival (P = 0.03, hazard ratio 0.11, 95% confidence interval 0.10-0.82).

CONCLUSIONS:

High expression of growth factor receptor-binding protein 14 in breast cancer cells may help to identify low-risk patients for additional therapies after neoadjuvant chemotherapy.

• Authors: Ou Huang, Min Jiang, Xi Zhang, Zuoquan Xie, Xiaosong Chen, Jiayi Wu, Hongchun Liu, Kunwei Shen
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 43 Issue 11 Pg. 1064-72 (Nov 2013) ISSN: 1465-3621 [Electronic] England
• PMID: 24031083 (Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• Biomarkers, Tumor
• GRB14 protein, human

Topics

• Adaptor Proteins, Signal Transducing (analysis)
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Asian People (statistics & numerical data)
• Biomarkers, Tumor (analysis)
• Breast Neoplasms (chemistry, drug therapy, mortality, pathology, surgery)
• China (epidemiology)
• Disease-Free Survival
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Middle Aged
• Multivariate Analysis
• Neoadjuvant Therapy (methods)
• Neoplasm Grading
• Neoplasm Staging
• Odds Ratio
• Predictive Value of Tests
• Prognosis
• Proportional Hazards Models
• Prospective Studies
• Up-Regulation