Abstract | BACKGROUND: Little information is available about the risk of progression of seemingly benign adrenocortical hyperplasias to carcinomatous conditions. Using in silico approaches of digitally archived tissue sections, the nuclear morphometric parameters were compared to assess nuclear asymmetry as an index for nuclear atypia. METHODS: Four groups of nuclei were used for the current study: spongiocytes and compact cells obtained from adrenocorticotropic hormone ( ACTH)-independent macronodular hyperplasia, which were hypothesized to be high risk for nuclear asymmetry, and primary pigmented nodular adrenocortical disease and micronodular adrenocortical hyperplasia samples were used as internal controls. RESULTS: CONCLUSIONS: This probably puts this class of adrenocortical tumors at risk of dysplastic progression, and more studies are needed to test the hypothesis.
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Authors | Qian Zhang, Jingtao Dou, Weijun Gu, Guoqing Yang, Yiming Mu, Juming Lu |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 347
Issue 5
Pg. 400-5
(May 2014)
ISSN: 1538-2990 [Electronic] United States |
PMID | 24029797
(Publication Type: Journal Article)
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Topics |
- Cell Nucleus
(pathology)
- Computer Simulation
- Cushing Syndrome
(diagnosis, pathology)
- Humans
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