HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Neuropharmacological lesion localization in idiopathic Horner's syndrome in Golden Retrievers and dogs of other breeds.

AbstractOBJECTIVE:
To investigate whether idiopathic Horner's syndrome (HS) in Golden Retrievers is an exclusively preganglionic disorder based on denervation hypersensitivity pharmacological testing with phenylephrine.
ANIMALS STUDIED:
Medical records of dogs presented with HS between 2000 and 2012. Dogs presented with additional ocular or systemic signs were excluded.
PROCEDURES:
Clinical data examined included age, sex, duration of clinical signs, ancillary diagnostic test results, and time to mydriasis on topical ocular application of 1% phenylephrine. Lesions were diagnosed as postganglionic (mydriasis within 20 min) or preganglionic (mydriasis between 20 and 45 min).
RESULTS:
Medical records of 21 dogs of nine different breeds were included. An etiopathogenesis for Horner's syndrome was determined in five dogs, none of which were Golden Retrievers. All diagnoses correlated with pharmacological lesion localization. Ten Golden Retrievers were included (eight male and two female) with a mean age of 8.5 years (range: 4-13). Lesion localization was diagnosed as postganglionic in eight (mean: 10 min [range: 6-18]) and preganglionic in two Golden Retrievers (20 and 24 min). All cases were unilateral and had completely resolved within 15 weeks (range: 11-20). Recurrence was not reported in any of the patients.
CONCLUSIONS:
Idiopathic postganglionic HS was diagnosed in eight of 10 Golden Retrievers contradicting previous reports of a purely preganglionic localization. Etiopathogenesis of canine idiopathic HS remains to be determined; nevertheless, a vascular etiology cannot be excluded. Future studies using magnetic resonance angiography may aid in clarifying the pathogenesis.
AuthorsKatherine M Simpson, David L Williams, Giunio B Cherubini
JournalVeterinary ophthalmology (Vet Ophthalmol) Vol. 18 Issue 1 Pg. 1-5 (Jan 2015) ISSN: 1463-5224 [Electronic] England
PMID24028692 (Publication Type: Journal Article)
Copyright© 2013 American College of Veterinary Ophthalmologists.
Chemical References
  • Sympathomimetics
  • Phenylephrine
Topics
  • Animals
  • Autonomic Fibers, Preganglionic (drug effects, pathology)
  • Blepharoptosis (diagnosis, pathology, veterinary)
  • Dog Diseases (diagnosis, pathology)
  • Dogs
  • Female
  • Horner Syndrome (diagnosis, pathology, veterinary)
  • Male
  • Miosis (diagnosis, pathology, veterinary)
  • Phenylephrine (pharmacology)
  • Species Specificity
  • Sympathetic Fibers, Postganglionic (drug effects, pathology)
  • Sympathomimetics (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: