In vitro demonstration of synergy/additivity between (188)rhenium and sorafenib on hepatoma lines: preliminary results.

Abstract

BACKGROUND:

Hepatocellular carcinoma is generally diagnosed at advanced stages, for which only palliative treatments are possible by intra-arterial route or by targeted therapies. Among these treatments, metabolic radiotherapy using (90)-yttrium or (188)Re and sorafenib are two options adopted in monotherapy.

MATERIALS AND METHODS:

We address the question of a possible synergy arising from the combination of these two treatments. Two primary malignant hepatoma cell lines, N1S1 (murine HCC) and HepG2 (human hepatoblastoma) were treated in media containing increasing concentrations of sorafenib with/without (188)Re to assess the cellular toxicities of each treatment alone and in combination. The combination index method was used to look for synergy or additivity.

RESULTS:

A synergistic advantage of a treatment combining (188)Re and sorafenib is shown in vitro on hepatoma cell lines.

CONCLUSION:

This combined approach is promising and now needs to be confirmed by more complex in vitro models integrating the tumoral stroma, as well as by in vivo studies.

• Authors: Marc Pracht, Julien Edeline, Nicolas Lepareur, Laurence Lenoir, Valerie Ardisson, Bruno Clement, Jean-Luc Raoul, Odile Audrain, Evelyne Boucher, Etienne Garin
• Journal: Anticancer research (Anticancer Res) Vol. 33 Issue 9 Pg. 3871-7 (Sep 2013) ISSN: 1791-7530 [Electronic] Greece
• PMID: 24023322 (Publication Type: Journal Article)

Chemical References

• Phenylurea Compounds
• Radioisotopes
• Niacinamide
• Rhenium
• Sorafenib

Topics

• Animals
• Carcinoma, Hepatocellular (drug therapy, radiotherapy)
• Cell Line
• Cell Line, Tumor
• Combined Modality Therapy
• Humans
• In Vitro Techniques
• Liver Neoplasms (drug therapy, radiotherapy)
• Mice
• Niacinamide (analogs & derivatives, therapeutic use)
• Phenylurea Compounds (therapeutic use)
• Radioisotopes (pharmacology)
• Rhenium (pharmacology)
• Sorafenib