Abstract | BACKGROUND: METHODS: We enrolled 20 children and adolescents with PKU and 20 matched controls. Multi-elementary quantification was carried out by solution-based inductively coupled plasma atomic emission spectroscopy (ICP-AES) and ICP mass spectrometry (ICP-MS). RESULTS: With the exception of manganese and aluminium, no significant differences were found for element levels between PKU patients and controls. As a trend, manganese levels were lower in PKU patients than in control subjects (p < 0.05) but were within the reference range. There was a positive linear relationship between manganese and tyrosine levels in subjects with PKU (r(2) = 0.2295, p < 0.05). If detectable, potentially toxic elements were only identified in ultra-trace quantities in plasma samples of either group; aluminium levels were found to be slightly higher in PKU subjects than in controls (p < 0.01). CONCLUSION: The combination of ICP-AES and ICP-MS data is a useful diagnostic tool for element quantification at a high analytical rate and for monitoring bio- element status, e.g. in patients on a restrictive diet.
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Authors | I Knerr, H Blessing, S Seyferth, R J Watling, M A Chaudhri |
Journal | Annals of nutrition & metabolism
(Ann Nutr Metab)
Vol. 63
Issue 1-2
Pg. 168-73
( 2013)
ISSN: 1421-9697 [Electronic] Switzerland |
PMID | 24021752
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
- Trace Elements
- Phenylalanine
|
Topics |
- Adolescent
- Case-Control Studies
- Child
- Child, Preschool
- Diet
- Energy Intake
- Female
- Humans
- Linear Models
- Male
- Mass Spectrometry
(methods)
- Nutritional Status
- Phenylalanine
(administration & dosage, blood)
- Phenylketonurias
(blood)
- Reference Values
- Spectrophotometry, Atomic
(methods)
- Trace Elements
(blood)
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