Abstract | BACKGROUND: OBJECTIVE: METHODS: Two experimental groups of brown Norway rats sensitized and repeatedly challenged with aerosolized ovalbumin (OA) were given oral zileuton (OA- zileuton group) and oral saline only (OA-saline group). A third, control group was sensitized and challenged by saline. The rats were anesthetized and paralyzed. Pulmonary function tests were performed at baseline and after varying doses of acetylcholine. Bronchoalveolar lavage fluid and lung tissues were examined. RESULTS: CONCLUSION:
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Authors | Wei-Ji Chen, Shwu-Fang Liaw, Ching-Chi Lin, Mei-Wei Lin, Feng-Ting Chang |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 86
Issue 5
Pg. 421-9
( 2013)
ISSN: 1423-0356 [Electronic] Switzerland |
PMID | 24021192
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 S. Karger AG, Basel. |
Chemical References |
- Allergens
- Leukotriene Antagonists
- Phosphatidylinositol 3-Kinases
- zileuton
- Hydroxyurea
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Topics |
- Airway Remodeling
(drug effects, immunology)
- Allergens
(administration & dosage)
- Animals
- Asthma
(drug therapy, immunology, metabolism, pathology)
- Bronchoalveolar Lavage Fluid
(cytology, immunology)
- Drug Evaluation, Preclinical
- Hydroxyurea
(analogs & derivatives, pharmacology, therapeutic use)
- Leukotriene Antagonists
(pharmacology, therapeutic use)
- Lung
(drug effects, immunology, pathology)
- MAP Kinase Signaling System
- Male
- Phosphatidylinositol 3-Kinases
(metabolism)
- Rats
- Respiratory Function Tests
- T-Lymphocytes
(metabolism)
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