An infant with prenatally diagnosed congenital anaplastic astrocytoma who remains disease-free after proton therapy.

Abstract

The authors present a rare of prenatally diagnosed congenital anaplastic astrocytoma. A 9-month-old boy had three recurrences despite two surgical resections and various chemotherapeutic regimens. He underwent the 3rd gross tumor removal at 11 months of age, followed by proton therapy, and now he remains disease-free for 3 yr without a significant neurocognitive dysfunction. This is the 1st case of a pediatric tumor treated by proton therapy in Korea, and proton therapy may be a treatment of choice for a congenital anaplastic astrocytoma in infants and young children, considering limitation of radiation therapy.

• Authors: Hyun Jung Shin, Young Joo Kwon, Hyeon Jin Park, Byung Kiu Park, Sang Hoon Shin, Joo-Young Kim, Sang Hyun Lee, Heung Sik Kim, Dong Won Kim
• Journal: Journal of Korean medical science (J Korean Med Sci) Vol. 28 Issue 9 Pg. 1394-8 (Sep 2013) ISSN: 1598-6357 [Electronic] Korea (South)
• PMID: 24015049 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Astrocytoma (diagnosis, radiotherapy, surgery)
• Brain Neoplasms (diagnosis, radiotherapy, surgery)
• Disease-Free Survival
• Humans
• Infant
• Magnetic Resonance Imaging
• Male
• Prenatal Diagnosis
• Proton Therapy
• Tomography, X-Ray Computed