Preterm premature
rupture of membranes (
PPROM) is defined as a spontaneous membrane
rupture that occurs before the onset of labor and 37 weeks gestation. Subclinical intrauterine
infection has been suggested as a very important etiological factor in the pathogenesis and subsequent morbidity related with
PPROM. This study was performed to assess the levels of maternal
proadrenomedullin (pro-ADM) and
serum amyloid A (AA) in
PPROM and its association with fetomaternal infectious morbidity. A total of 63 pregnant women, of which 43 with
PPROM between 24 and 34 weeks gestation and 20 normal pregnant women without
PPROM were included in the study. The study group was separated into 2 subgroups as
PPROM and
PPROM-histological
chorioamnionitis (
PPROM-HC). The blood samples were taken before the administration of any medication. The mean serum
interleukin-6 (IL-6), AA, and pro-ADM values in the
PPROM-HC group were significantly higher than the
PPROM and control group. The cutoff values of pro-ADM and AA were determined as 4.2 nM and 69 μg/mL, respectively. Both of them showed similar sensitivity, specificity to
IL-6 and a better sensitivity and specificity as compared to
C-reactive protein and white blood cell count. We determined the predictive value of pro-ADM and serum AA measurements in
PPROM and
PPROM with histological
chorioamnionitis. We suggest using pro-ADM and serum AA
biomarkers for detecting the histological
chorioamnionitis at an earlier stage in
PPROM without any clinical signs.