[Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism].

Abstract

OBJECTIVE:

To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism.

METHOD:

Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group, the model group, the psoralidine low-dose group (4 mg x kg(-1)), the psoralidine high-dose group (16 mg x kg(-1)) and the Zhuangguzhitong capsule group, with 12 rats in each group. Thirteen weeks later, their blood and bone samples were collected to detect bone density, bone biochemistry, pathomorphology, serum E2 and CT.

RESULT:

Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy (P < 0.05), the maximum bending strength of thighbone (P < 0.05), and serum E2 and CT (P < 0.05).

CONCLUSION:

Psoralidine has a good active effect on postmenopausal antiosteoporosis. Its mechanism may be related to such pathways as E2 and CT.

• Authors: Jin-Ping Li, Xiao-Jing Wang, Ying Zeng, Qing Lin, Xin-Min Mo, Shi-Jie Liu, Jun Yang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 38 Issue 11 Pg. 1816-9 (Jun 2013) ISSN: 1001-5302 [Print] China
• PMID: 24010302 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzofurans
• Coumarins
• Drugs, Chinese Herbal
• Estradiol
• psoralidin

Topics

• Animals
• Benzofurans (administration & dosage)
• Bone Density (drug effects)
• Coumarins (administration & dosage)
• Drugs, Chinese Herbal (administration & dosage)
• Estradiol (blood)
• Female
• Humans
• Osteoporosis, Postmenopausal (blood, drug therapy, physiopathology)
• Rats
• Rats, Sprague-Dawley