Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells.

Abstract

Liposarcoma is the second most common soft tissue sarcoma in adults, but treatment options have been quite limited thus far. In this study, we investigated the functional and therapeutic relevance of cyclin-dependent kinase 11 (CDK11) as a putative target in liposarcoma. CDK11 knockdown by synthetic siRNA or lentiviral shRNA decreased cell proliferation, and induced apoptosis in liposarcoma cells. Moreover, CDK11 knockdown enhances the cytotoxic effect of doxorubicin to inhibit cell growth in liposarcoma cells. These findings suggest that CDK11 is critical for the growth and proliferation of liposarcoma cells. CDK11 may be a promising therapeutic target for the treatment of liposarcoma patients.

• Authors: Bin Jia, Edwin Choy, Gregory Cote, David Harmon, Shunan Ye, Quancheng Kan, Henry Mankin, Francis Hornicek, Zhenfeng Duan
• Journal: Cancer letters (Cancer Lett) Vol. 342 Issue 1 Pg. 104-12 (Jan 01 2014) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 24007862 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antibiotics, Antineoplastic
• RNA, Small Interfering
• Doxorubicin
• CDK11a protein, human
• Cyclin-Dependent Kinases

Topics

• Antibiotics, Antineoplastic (pharmacology)
• Apoptosis
• Cell Line, Tumor
• Cell Proliferation
• Cell Survival
• Cyclin-Dependent Kinases (genetics, metabolism)
• Doxorubicin (pharmacology)
• Female
• Gene Knockdown Techniques
• Humans
• Lipoma (enzymology)
• Liposarcoma (enzymology, mortality, pathology)
• Male
• Middle Aged
• RNA, Small Interfering (genetics)
• Tissue Array Analysis