Serum allergen-specific IgA is not associated with natural or induced tolerance to egg in children.

Abstract

The role of specific IgA (sIgA) in oral immunotherapy (OIT) and natural tolerance to foods is poorly understood. We aimed to study serum sIgA in induced and natural tolerance to egg. Children aged 5-16 years diagnosed with IgE-mediated egg allergy were recruited. After egg challenge, patients were classified as transient (TEA) or persistent (PEA) egg-allergic. PEA children were further divided into oral immunotherapy (PEA-OIT) or egg avoidance (PEA-EA). Allergy/tolerance was reassessed 9-12 months later (T1) in PEA-EA. Serum sIgA to ovalbumin and ovomucoid were determined at inclusion in all patients and repeated in PEA at T1. 21 TEA and 52 PEA children were recruited (28 PEA-OIT, 24 PEA-EA). Serum sIgA remained unchanged after OIT. TEA and PEA had similar serum sIgA. No specific trend on serum sIgA was observed in five PEA-EA who developed natural tolerance over follow-up. Thus, serum sIgA seems not to be associated with induced or natural egg tolerance.

• Authors: M Vazquez-Ortiz, M Pascal, M Juan, L Alsina, M A Martín-Mateos, A M Plaza
• Journal: Allergy (Allergy) Vol. 68 Issue 10 Pg. 1327-32 (Oct 2013) ISSN: 1398-9995 [Electronic] Denmark
• PMID: 24004369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Allergens
• Immunoglobulin A
• Ovomucin
• Immunoglobulin E
• Ovalbumin

Topics

• Adolescent
• Allergens (immunology)
• Antibody Specificity (immunology)
• Child
• Child, Preschool
• Desensitization, Immunologic
• Egg Hypersensitivity (blood, diagnosis, immunology, therapy)
• Eggs (adverse effects)
• Female
• Humans
• Immune Tolerance
• Immunoglobulin A (blood, immunology)
• Immunoglobulin E (blood, immunology)
• Male
• Ovalbumin (immunology)
• Ovomucin (immunology)