[Efficiency of cycloferon against slow viral infection caused by SV-40 in monkeys and man].

Abstract

The latent infection caused by Simian virus (SV-40) defeats monkeys and others animals. Currently there are not the prophylactic and therapeutic measures against this disease. We showed the infringement of immunity of M. mulatta infected by SV-40. The use of the preparation Cyclopheron for the treatment of this infection led to the normalization of the functions of immunity of monkeys and to disappearance of the virus from the organism. We suggested the new method for prophylaxis and treatment of latent SV-40 infection by Cyclopheron, may be used for the correction of the immunity.

• Authors: M V Mezentseva, V Z Agrba, A A Agumava, B A Lapin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 76 Issue 6 Pg. 27-9 ( 2013) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 24003487 (Publication Type: Journal Article)

Chemical References

• Acridines
• Antibodies, Viral
• Cytokines
• DNA, Viral
• Interferon Inducers
• 10-carboxymethyl-9-acridanone

Topics

• Acridines (pharmacology)
• Adult
• Animals
• Antibodies, Viral (biosynthesis)
• Asymptomatic Diseases
• B-Lymphocytes (drug effects, immunology, virology)
• Cytokines (biosynthesis, immunology)
• DNA, Viral (antagonists & inhibitors)
• Humans
• Interferon Inducers (pharmacology)
• Macaca mulatta
• Male
• Middle Aged
• Polyomavirus Infections (drug therapy, immunology, virology)
• Simian virus 40 (drug effects, immunology)
• T-Lymphocytes (drug effects, immunology, virology)
• Treatment Outcome
• Tumor Virus Infections (drug therapy, immunology, virology)
• Virus Replication (drug effects)