Abstract | CONTEXT: OBJECTIVE: The purpose of this work was to assess the clinical, hormonal, histological, and molecular features of NIPs. DESIGN: This was a retrospective cohort recruited from 2001 to 2011 in 2 tertiary care medical departments. PATIENTS AND METHODS: RESULTS:
Tumor size and metaiodobenzylguanidine ( MIBG) scintigraphy results were similar for hypertensive pheochromocytomas (HPs) and NIPs. Patients with NIPs displayed reduced summed levels of urinary catecholamines and metanephrines and, more specifically, reduced levels of adrenaline and metadrenaline compared with those of patients with HPs (P < .001). Urinary metanephrines had 98% diagnostic sensitivity in patients with HPs and only 75% in patients with NIPs (P < .01). Tumor diameter positively correlated with the total amount of urinary concentrations of metanephrines in patients with HPs (P < .001) but not in patients with NIPs. NIPs displayed global decreased chromaffin gene expression (reaching significance for 5 of them) and 2 corresponding proteins ( phenylethanolamine N-methyltransferase and secretogranin II) and a significant increase in the cellularity, mitotic activity, and presence of atypical mitosis (P < .05). CONCLUSIONS:
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Authors | Magalie Haissaguerre, Maïté Courel, Philippe Caron, Sophie Denost, Christophe Dubessy, Philippe Gosse, Vincent Appavoupoulle, Geneviève Belleannée, Marie-Laure Jullié, Maité Montero-Hadjadje, Laurent Yon, Jean-Benoît Corcuff, Cédric Fagour, Catherine Mazerolles, Tristan Wagner, Marie-Laure Nunes, Youssef Anouar, Antoine Tabarin |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 98
Issue 11
Pg. 4346-54
(Nov 2013)
ISSN: 1945-7197 [Electronic] United States |
PMID | 24001749
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radiopharmaceuticals
- 3-Iodobenzylguanidine
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Topics |
- 3-Iodobenzylguanidine
- Adrenal Gland Neoplasms
(diagnostic imaging, genetics, metabolism)
- Chromaffin Cells
(diagnostic imaging, pathology, physiology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Hypertension
(diagnostic imaging, genetics, metabolism)
- Incidental Findings
- Male
- Middle Aged
- Pheochromocytoma
(diagnostic imaging, genetics, metabolism)
- Radionuclide Imaging
- Radiopharmaceuticals
- Retrospective Studies
- Transcriptome
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