[Hepato- and endothelioprotective action of runihol and ademetionine in experimental liver injury induced by TB drugs in combination with alcohol].

Abstract

Hepato- and endothelioprotective action of runihol and ademetionine in 66 male rats with liver disease induced by essential and second-line antituberculosis drugs in combination with alcohol were studied. One-directed affirmative action study drugs, shown to reduce the level of biochemical markers of cytolysis and cholestasis in conjunction with a significant reduction in symptoms of fatty, hyaline droplet and hydropic degeneration. In this runihol had a more pronounced anticytolitic effect, while under the influence of ademethionine the normalization endothelial dysfunction was established.

• Authors: D S Sukhanov, E B Artyushkova, V T Dudka
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 2013 Apr-Jun Issue 2 Pg. 45-9 ISSN: 0031-2991 [Print] Russia (Federation)
• PMID: 24000714 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antitubercular Agents
• S-Adenosylmethionine

Topics

• Animals
• Antitubercular Agents (toxicity)
• Cholestasis (drug therapy)
• Endothelium (drug effects, pathology)
• Hyalin (metabolism)
• Lipid Metabolism
• Liver (drug effects, pathology)
• Liver Diseases, Alcoholic (drug therapy, prevention & control)
• Male
• Rats
• S-Adenosylmethionine (therapeutic use)