Association between single-nucleotide polymorphisms of OGG1 gene and pancreatic cancer risk in Chinese Han population.

Abstract

The purpose of this study was to test the association between single-nucleotide polymorphisms (SNPs) of 8-oxoguanine DNA glycosylase (OGG1) gene and susceptibility to pancreatic cancer (PC). A total of 347 PC patients and 364 healthy subjects were enrolled in this case-control study. The c.269C>A genetic variant was investigated using the created restriction site-polymerase chain reaction method. The c.627T>C genetic variant was identified by the polymerase chain reaction-restriction fragment length polymorphism method. Our data indicated that the alleles and genotypes frequencies of these two SNPs were statistically different in PC cases and controls. As for c.269C>A, the AA genotype was statistically associated with decreased PC susceptibility compared to CC wild genotype (odds ratio (OR) = 0.44, 95% confidence interval (CI) 0.27-0.73, P = 0.001). As for c.627T>C, statistically significant decreased PC susceptibility was detected in CC genotype compared to TT wild genotype (OR = 0.57, 95% CI 0.35-0.94, P = 0.028). The allele A of c.269C>A and allele C of c.627T>C might be associated with a protection from PC (for c.269C>A, A versus (vs.) C, OR = 0.69, 95% CI 0.55-0.86, P < 0.001; for c.627T>C, C vs. T, OR = 0.72, 95% CI 0.58-0.91, P = 0.005). Results from this study indicate that the c.269C>A and c.627T>C SNPs of OGG1 gene are associated with PC susceptibility in Chinese Han ethnicity.

• Authors: Hongxu Chen, Bo Zhou, Xiang Lan, Dong Wei, Tao Yuan, Ping Chen
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 1 Pg. 809-13 (Jan 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 23999824 (Publication Type: Journal Article, Retracted Publication)

Chemical References

• DNA Glycosylases
• oxoguanine glycosylase 1, human

Topics

• Adult
• Aged
• Alleles
• Asian People (genetics)
• Case-Control Studies
• China
• DNA Glycosylases (genetics)
• Female
• Gene Frequency
• Genetic Association Studies
• Genotype
• Humans
• Male
• Middle Aged
• Odds Ratio
• Pancreatic Neoplasms (genetics)
• Polymorphism, Single Nucleotide
• Risk