[Expression of pituitary tumor transforming gene in patients with acute lymphoblastic leukemia].

Abstract

The aim of this study was to explore the expression of pituitary tumor-transforming gene (PTTG) in acute lymphoblastic leukemia (ALL) and its relationship with the pathogenesis of ALL, as well as study the difference of the PTTG expression in ALL patients with Ph1 chromosome and without Ph1 chromosome. The mRNA expressions of PTTG in bone marrow from 28 patients with ALL and 28 normal controls were quantitatively detected by real-time quantitative polymerase chain reaction (real-time PCR). The results indicated that the expression of PTTG mRNA was significantly higher in ALL patients (1.9428E5 ± 1.8372E5) than that in normal controls (4.5766E3 ± 1.1817E3) (P < 0.05). The expression of PTTG mRNA was higher in Ph1 chromosome positive patients. The initial expression of PTTG mRNA was lower in patients achieved complete remission than that in patients with non-complete remission. It is concluded that the overexpression of PTTG may be related to the progression and genesis of ALL. Overexpression of PTTG may be intimately related to the progression and genesis of Ph1 chromosome positive ALL. It provides a new ideas to research the pathogenesis and genic target treatment of ALL.

• Authors: Zhao Wang, Quan-Yi Lu, Xiao-Qing Niu, Peng Zhang, Ke-Jie Zhang
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 21 Issue 4 Pg. 835-8 (Aug 2013) ISSN: 1009-2137 [Print] China
• PMID: 23998569 (Publication Type: Controlled Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Securin
• pituitary tumor-transforming protein 1, human

Topics

• Adolescent
• Adult
• Aged
• Case-Control Studies
• Female
• Gene Expression
• Gene Expression Regulation, Leukemic
• Humans
• Male
• Middle Aged
• Philadelphia Chromosome
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics, metabolism)
• Securin (genetics)
• Young Adult