Abstract | PURPOSE: METHODS: We investigated both UCH-L1 mRNA expression in microarray data from 182 primary mammary carcinomas and UCH-L1 protein expression using a tissue microarray containing samples from 1,622 breast cancer patients. RESULTS: With both methods, high UCH-L1 expression correlated significantly with negative oestrogen receptor and progesterone receptor status and advanced tumour stage. Moreover by Kaplan-Meier analysis, high UCH-L1 mRNA and protein expression correlated with a significantly shorter overall survival. CONCLUSION: The data of our study suggest that high levels of UCH-L1 expression indicate a more aggressive tumour behaviour and might represent a potential target in breast cancer treatment.
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Authors | Christine Schröder, Karin Milde-Langosch, Florian Gebauer, Katharina Schmid, Volkmar Mueller, Ralph M Wirtz, Catherine Meyer-Schwesinger, Hartmut Schlüter, Guido Sauter, Udo Schumacher |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 139
Issue 10
Pg. 1745-55
(Oct 2013)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 23996067
(Publication Type: Journal Article)
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Chemical References |
- RNA, Messenger
- Ubiquitin carboxyl-Terminal Hydrolase L-1, human
- Ubiquitin Thiolesterase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
(enzymology, mortality, pathology)
- Carcinoma, Ductal, Breast
(enzymology, mortality, pathology)
- Cohort Studies
- Female
- Gene Expression
- Humans
- Kaplan-Meier Estimate
- Middle Aged
- Multivariate Analysis
- Oligonucleotide Array Sequence Analysis
- Prognosis
- RNA, Messenger
(genetics, metabolism)
- Tissue Array Analysis
- Ubiquitin Thiolesterase
(genetics, metabolism)
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