Neodymium-yttrium aluminum garnet laser versus pulsed dye laser in erythemato-telangiectatic rosacea: comparison of clinical efficacy and effect on cutaneous substance (P) expression.

Abstract

BACKGROUND:

Different laser systems are reported to be effective in treatment of telangiectasia and erythema, but comparative studies on 1064-nm neodymium-yttrium aluminum garnet (Nd-YAG) laser and pulsed dye laser (PDL) in treatment of erythemato-telangiectatic rosacea are lacking. Substance (P) is implicated in rosacea pathogenesis.

OBJECTIVES:

To compare the effect of Nd-YAG laser and PDL on erythemato-telangiectatic rosacea, both clinically and immunohistochemically on cutaneous substance (P) expression.

METHODS:

This split-face comparative study included 15 patients with erythemato-telangiectatic rosacea treated on the right side with Nd-YAG laser and on the left side with PDL: three sessions, 4 weeks apart. Evaluation of the patients was done using erythema and telangiectasia grading scores, patient's self-assessment, physicians' clinical assessment of the patient, and immunohistochemical assessment of substance (P).

RESULTS:

One month after the three laser sessions, excellent response was achieved in 73.3% of patients after Nd-YAG and in 53.3% of patients after PDL with significantly lower substance (P) concentration after Nd-YAG laser than after PDL. Positive correlations were found between the decrease in erythema and telangiectasia grading scores and the decrease in substance (P) concentration.

CONCLUSIONS:

The use of Nd-YAG laser and PDL appears to be safe and effective measures in treatment of erythemato-telangiectatic rosacea. Both types of laser decrease the concentration of substance (P) in the skin. This effect is more pronounced with Nd-YAG laser.

• Authors: Samar Abdallah M Salem, Nermeen S A Abdel Fattah, Samah M A Tantawy, Nafissa M A El-Badawy, Yasser A Abd El-Aziz
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 12 Issue 3 Pg. 187-94 (Sep 2013) ISSN: 1473-2165 [Electronic] England
• PMID: 23992160 (Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Substance P

Topics

• Adult
• Erythema (surgery)
• Female
• Humans
• Lasers, Dye (adverse effects, therapeutic use)
• Lasers, Solid-State (adverse effects, therapeutic use)
• Middle Aged
• Rosacea (metabolism, surgery)
• Severity of Illness Index
• Substance P (metabolism)
• Telangiectasis (surgery)