Abstract | BACKGROUND: METHODS: A total of 344 IgA nephropathy patients were involved in this study. Morphological changes were evaluated with the Oxford classification of IgA nephropathy. Enzyme Linked Immunosorbent Assay (ELISA) measured the urinary uromodulin level on the renal biopsy day. Follow up was done regularly on 185 patients. Time-average blood pressure, time-average proteinuria, estimated glomerular filtration rate (eGFR) and eGFR decline rate were caculated. Association between the urinary uromodulin level and the eGFR decline rate was analyzed with SPSS 13.0. RESULTS: We found that lower baseline urinary uromodulin levels (P = 0.03) and higher time-average proteinuria (P = 0.04) were risk factors for rapid eGFR decline in a follow-up subgroup of the IgA nephropathy cohort. Urinary uromodulin level was correlated with tubulointerstitial lesions (P = 0.016). Patients that had more tubular atrophy/interstitial fibrosis on the surface had lower urinary uromodulin levels (P = 0.02). CONCLUSIONS:
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Authors | Jingjing Zhou, Yuqing Chen, Ying Liu, Sufang Shi, Suxia Wang, Xueying Li, Hong Zhang, Haiyan Wang |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 8
Pg. e71023
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23990922
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Blood Pressure
- Cohort Studies
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Female
- Fibrosis
- Glomerular Filtration Rate
- Glomerulonephritis, IGA
(urine)
- Humans
- Inflammation
- Kidney
(pathology, physiopathology)
- Male
- Proteinuria
(diagnosis, urine)
- Renal Insufficiency, Chronic
(diagnosis, urine)
- Risk Factors
- Uromodulin
(urine)
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