Avidity of antibodies against HSV-2 and risk to neonatal transmission among Mexican pregnant women.

To determine HSV-2 seroprevalence, risk factors, and antibody avidity among a sample of Mexican pregnant women.
The avidity test was standardized with different urea concentrations and incubation times; the cut-off point was calculated to determine the low avidity (early infection). IgG antibodies against HSV-2 were detected from pregnant and postpartum women from Morelos, Mexico, and the avidity test was performed to positive samples. Multivariate regression logistic analysis was employed to evaluate demographic and sexual behavior characteristics associated with HSV-2 infection.
HSV-2 seroprevalence among Mexican women analyzed was 14.5% (333/2300), demographic factors (location of General Hospital, age, education level, and civil status), and risky sexual behaviors (STI self-report and number of sexual partners during last year) were associated with HSV-2 infection. Seventeen women were detected with low avidity antibodies (early infection) with a cut-off point of 66.1%.
HSV-2 infection was common among this group of women from Mexico; the avidity test detected women with recent infections, and these women were more likely to transmit HSV-2 to their neonates. Neonatal herpes has no epidemiological surveillance, the disease could be overlooked, and so more studies are needed to estimate the magnitude of neonatal infection.
AuthorsAntonia Herrera-Ortiz, Carlos Jesús Conde-Glez, Dayana Nicté Vergara-Ortega, Santa García-Cisneros, Ma Leonidez Olamendi-Portugal, Miguel Angel Sánchez-Alemán
JournalInfectious diseases in obstetrics and gynecology (Infect Dis Obstet Gynecol) Vol. 2013 Pg. 140142 ( 2013) ISSN: 1098-0997 [Electronic] Egypt
PMID23986628 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Viral
  • Adult
  • Antibodies, Viral (blood, immunology)
  • Antibody Affinity
  • Female
  • Herpes Genitalis (immunology, transmission, virology)
  • Herpesvirus 2, Human (immunology)
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Pregnancy
  • Pregnancy Complications, Infectious (immunology, virology)
  • Risk Factors
  • Seroepidemiologic Studies

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