[Human immunodeficiency virus-related non-hodgkin lymphoma: a clinical investigation at our hospital].

Abstract

We investigated 8 cases of non-Hodgkin lymphoma(NHL)in human immunodeficiency virus(HIV)seropositive individuals who were diagnosed and treated at Osaka City General Hospital between April 2002 and October 2012. All patients were men, and the average age at the onset of NHL was 46 years(range: 30-61). Histological types were as follows: diffuse large B cell lymphoma in 4 patients, plasmablastic lymphoma in 2 patients, primary effusion lymphoma in 1 patient, and Burkitt lymphoma in 1 patient. In 3 cases, HIV infection was identified before the onset of NHL. Highly active anti-retroviral therapy (HAART)was initiated in 6 cases, and in 4 of these, we administered antineoplastic chemotherapy. Three patients who did not receive antineoplastic chemotherapy died within 1 month of diagnosis. Although 1 of the patients who received chemotherapy achieved complete remission, this patient died of BK virus nephritis. The remaining 3 patients achieved complete remission and are currently alive after 6 to 9 months. We believe that the combination of antineoplastic chemotherapy with HAART will lead to prognostic improvement in HIV-seropositive patients with NHL.

• Authors: Yoshihiko Ogawa, Masahiro Yoshida, Hiroshi Kanashima, Takafumi Nakao, Michinori Sirano, Tetsushi Goto, Hiroko Fukushima, Takeshi Inoue, Takahisa Yamane
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 8 Pg. 1027-30 (Aug 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 23986045 (Publication Type: English Abstract, Journal Article)

Topics

• Adult
• Antiretroviral Therapy, Highly Active
• HIV Infections (complications, drug therapy)
• Humans
• Lymphoma, Non-Hodgkin (diagnosis, drug therapy, etiology)
• Male
• Middle Aged
• Prognosis