Antitumor, antioxidant and antimicrobial studies of substituted pyridylguanidines.

Abstract

A series of N-pivaloyl-N'-(alkyl/aryl)-N''-pyridylguanidine of general formula C₄H₉CONHC(NR¹R²)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.

• Authors: Muhammad Said, Amin Badshah, Naseer Ali Shah, Hizbullah Khan, Ghulam Murtaza, Boris Vabre, Davit Zargarian, Muhammad Rashid Khan
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 18 Issue 9 Pg. 10378-96 (Aug 27 2013) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 23985956 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Antifungal Agents
• Antineoplastic Agents
• Biphenyl Compounds
• Free Radical Scavengers
• Free Radicals
• Guanidines
• Picrates
• Pyridines
• Vincristine
• 1,1-diphenyl-2-picrylhydrazyl

Topics

• Anti-Bacterial Agents (chemical synthesis, pharmacology)
• Antifungal Agents (chemical synthesis, pharmacology)
• Antineoplastic Agents (chemical synthesis, pharmacology)
• Biphenyl Compounds (chemistry)
• Disk Diffusion Antimicrobial Tests (standards)
• Drug Screening Assays, Antitumor
• Free Radical Scavengers (chemical synthesis, pharmacology)
• Free Radicals
• Guanidines (chemical synthesis, pharmacology)
• Models, Molecular
• Molecular Conformation
• Picrates (chemistry)
• Plant Tumors (microbiology)
• Pyridines (chemical synthesis, pharmacology)
• Reference Standards
• Vincristine (pharmacology)
• X-Ray Diffraction