Laser assisted urethral closure in the rat: comparison of CO2 and Neodymium-YAG laser techniques.

In 65 male rats a comparative study was undertaken to investigate a Neodymium-YAG and CO2 laser system for the microsurgical repair of longitudinal incisions of the rat urethra. Postoperative investigations included patency tests, necropsy and light microscopy. Use of the laser systems did not reduce operation time. The highest rate of postoperative strictures (90%), urethral fistulas (30%), urinomas (20%) and postoperative deaths (70%) was seen in the Neodymium-YAG laser group. CO2 laser repair was almost as efficacious as microsuture repair, except for a higher rate of urethral fistulas resulting from the initially weak laser weld. Based on these findings, the Neodymium-YAG laser seems unsuitable for urethral repair. Further studies in larger animals are warranted using a CO2 laser in combination with postoperative cystostomy for urinary diversion in order to avoid fistulas in the early postoperative period.
AuthorsR A Bürger, C D Gerharz, H Bunn, U H Engelmann, R Hohenfellner
JournalThe Journal of urology (J Urol) Vol. 144 Issue 4 Pg. 1000-3 (Oct 1990) ISSN: 0022-5347 [Print] United States
PMID2398546 (Publication Type: Comparative Study, Journal Article)
  • Animals
  • Laser Therapy (adverse effects, methods)
  • Male
  • Rats
  • Rats, Inbred Strains
  • Urethra (pathology, surgery)
  • Urethral Diseases (etiology)
  • Urethral Stricture (etiology)
  • Urinary Fistula (etiology)
  • Wound Healing

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!

Choose Username:
Verify Password:
Enter Code Shown: