Abstract | OBJECTIVE: STUDY DESIGN: A total of 3779 subjects from Piracicaba, Säo Paulo, Brazil were screened; 284 had at least one leathery primary root caries lesion and were eligible for the study. The new dentifrice contained 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate; the matched positive control dentifrice contained 1450 ppm fluoride. One lesion for each subject was selected for inclusion in the study and was examined at baseline, 3 and 6 months. RESULTS: A total of 253 subjects completed the study with 129 of 144 subjects included in the final statistical analysis for the test dentifrice and 124 of 140 for the positive control. The mean age of subjects was 45.7 (±9.19) years and 56.5% were female. After 6 months product use, 70.5% of root caries lesions improved for subjects using the arginine-containing dentifrice compared to 58.1% for subjects using the positive control. The difference in the number of root caries lesions becoming hard in the two groups was statistically significant (p=0.038). CONCLUSION:
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Authors | M L R Souza, J A Cury, L M A Tenuta, Y P Zhang, L R Mateo, D Cummins, R P Ellwood |
Journal | Journal of dentistry
(J Dent)
Vol. 41 Suppl 2
Pg. S35-41
(Aug 2013)
ISSN: 1879-176X [Electronic] England |
PMID | 23985437
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Cariostatic Agents
- Dentifrices
- Phosphates
- pro-argin
- Arginine
- Calcium Carbonate
- Fluorides
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Topics |
- Adult
- Aged
- Arginine
(therapeutic use)
- Calcium Carbonate
(therapeutic use)
- Cariostatic Agents
(therapeutic use)
- Dental Enamel
(drug effects, pathology)
- Dental Plaque Index
- Dentifrices
(therapeutic use)
- Female
- Fluorides
(therapeutic use)
- Follow-Up Studies
- Gingiva
(pathology)
- Hardness
- Humans
- Male
- Middle Aged
- Phosphates
(therapeutic use)
- Root Caries
(pathology, prevention & control)
- Tooth Remineralization
(methods)
- Treatment Outcome
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