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Chloroquine-induced Acute Dystonic Reactions after a Standard Therapeutic Dose for Uncomplicated Malaria.

Abstract
Acute dystonic reactions (ADR) are extrapyramidal effects that usually occur after the initiation of a wide variety of drugs or triggering factors besides neuroleptics. We report the case of a 54-year-old man who was admitted with an approximately 10-hour history of muscle twitching around the eyes, face and neck after he took the first dose of oral chloroquine phosphate (1 g [600 mg base]) prescribed for uncomplicated malaria. He was given intravenous diazepam (10 mg statum) followed by 10 mg of oral diazepam 3 times a day. The symptoms improved within 30 minutes of treatment, and he was discharged 14 hours later after a complete recovery.
AuthorsOlusegun A Busari, Joseph Fadare, Segun Agboola, Olusegun Gabriel, Olayide Elegbede, Yusuf Oladosu
JournalSultan Qaboos University medical journal (Sultan Qaboos Univ Med J) Vol. 13 Issue 3 Pg. E476-8 (Aug 2013) ISSN: 2075-051X [Print] Oman
PMID23984041 (Publication Type: Journal Article)

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