Down-regulation of stromal caveolin-1 expression in esophageal squamous cell carcinoma: a potent predictor of lymph node metastases, early tumor recurrence, and poor prognosis.

Abstract

BACKGROUND:

Recent studies have identified loss of stromal caveolin-1 (Cav-1) expression as a new prognostic histological characteristic in various types of human cancers. However, the clinical and pathological significance of stromal Cav-1 expression in esophageal squamous cell carcinoma (ESCC) remains largely unknown. We examined Cav-1 expression in both tumor and stromal cells in ESCC tissue by immunohistochemical analysis to evaluate its clinicopathological significance and prognostic value.

METHODS:

A total of 110 patients with ESCC who underwent surgical resection were included in this study. The expression of Cav-1 in both tumor and stromal cells in esophageal tumor tissues was examined immunohistochemically.

RESULTS:

Cav-1 expression was found in the cytoplasm of both tumor and stromal cells. Tumor Cav-1 overexpression was observed in 37.3 % tumors, which correlated to deeper tumor invasion (p = 0.038). Down-regulation of stromal Cav-1 expression was observed in 40.9 % tumors. The stromal Cav-1 down-regulation group had more lymph node metastases and more locoregional recurrences than those with higher expression (p = 0.020 and p = 0.002, respectively). In addition, down-regulation of stromal Cav-1 expression was associated with shorter disease-free survival (p < 0.001) and overall survival (p < 0.001). Multivariate analysis revealed that down-regulation of stromal Cav-1 expression was an independent prognostic factor for both disease-free survival (p = 0.028) and overall survival (p = 0.007).

CONCLUSIONS:

Down-regulation of stromal Cav-1 expression in ESCC had high malignant potential. It predicts high-risk of lymph node metastases and locoregional recurrence, and it could be a powerful prognostic marker for patients with ESCC.

• Authors: Yibin Jia, Nana Wang, Jianbo Wang, Hui Tian, Wei Ma, Kai Wang, Bingxu Tan, Guangyu Zhang, Shengsi Yang, Bing Bai, Yufeng Cheng
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 21 Issue 1 Pg. 329-36 (Jan 2014) ISSN: 1534-4681 [Electronic] United States
• PMID: 23982252 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Caveolin 1

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (metabolism, mortality, secondary)
• Caveolin 1 (metabolism)
• Down-Regulation
• Esophageal Neoplasms (metabolism, mortality, pathology)
• Female
• Follow-Up Studies
• Humans
• Immunoenzyme Techniques
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Grading
• Neoplasm Recurrence, Local (metabolism, mortality, pathology)
• Neoplasm Staging
• Prognosis
• Retrospective Studies
• Stromal Cells (metabolism, pathology)
• Survival Rate