Impact of exercise training on redox signaling in cardiovascular diseases.

Abstract

Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the pathogenesis and progression of cardiovascular diseases. In this review, we address how redox signaling and oxidant stress affect the pathophysiology of cardiovascular diseases such as ischemia-reperfusion injury, hypertension and heart failure. We also summarize the benefits of exercise training in tackling the hyperactivation of cellular oxidases and mitochondrial dysfunction seen in cardiovascular diseases.

• Authors: Juliane C Campos, Kátia M S Gomes, Julio C B Ferreira
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 62 Pg. 107-19 (Dec 2013) ISSN: 1873-6351 [Electronic] England
• PMID: 23978413 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antioxidants
• Reactive Oxygen Species

Topics

• Antioxidants (metabolism)
• Cardiovascular Diseases (metabolism, physiopathology)
• Exercise (physiology)
• Humans
• Mitochondria (metabolism)
• Oxidation-Reduction
• Oxidative Stress
• Reactive Oxygen Species (metabolism)
• Signal Transduction