Abstract | AIM: METHODS: Newborn rats were exposed to >95% O2 in the first week after birth, then to 60% O2 in the following 2 weeks. Control pups were exposed to room air over the same periods. The pups were injected with either Rho-kinase inhibitor Y-27632 (10 mg·kg(-1)·d(-1), ip) or vehicle from postnatal d 14 to 20. Lung and heart tissues were collected on postnatal d 7 and 21. Rho-kinase activity in lungs was measured using Western blotting and immunohistochemistry. The right ventricular hypertrophy and arterial medial wall thickness (MWT) were assessed morphologically. RESULTS: CONCLUSION:
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Authors | Hsiu-Chu Chou, Liang-Ti Huang, Tsu-Fu Yeh, Chung-Ming Chen |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 34
Issue 10
Pg. 1310-6
(Oct 2013)
ISSN: 1745-7254 [Electronic] United States |
PMID | 23974518
(Publication Type: Journal Article)
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Chemical References |
- Amides
- Antihypertensive Agents
- Pyridines
- Y 27632
- rho-Associated Kinases
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Topics |
- Amides
(pharmacology)
- Animals
- Animals, Newborn
- Antihypertensive Agents
(pharmacology)
- Blotting, Western
- Disease Models, Animal
- Female
- Hyperoxia
(complications)
- Hypertension, Pulmonary
(drug therapy, physiopathology)
- Hypertrophy, Right Ventricular
(drug therapy, physiopathology)
- Male
- Pyridines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Time Factors
- rho-Associated Kinases
(antagonists & inhibitors, genetics, metabolism)
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