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Effect of chemotherapy on elevated ejaculation time and deteriorated semen characteristics consequent to bovine trypanosomiasis.

Abstract
The effect of the trypanocidal drug Novidium on elevated ejaculation time and deteriorated semen characteristics was studied in Zebu cattle infected with T. vivax and T. congolense. Two groups, comprising six bulls per group, were infected with Trypanosoma vivax or Trypanosoma congolense while three bulls served as controls. Chemotherapy was carried out 12 weeks post-infection on three bulls from each group, leaving three bulls untreated while three bulls served as uninfected controls. Blood samples from treated bulls were all negative for trypanosomes 3 days post-chemotherapy. The animals also had normal body temperature. As the study progressed, clinical signs associated with trypanosomiasis, such as anaemia and cachexia, disappeared gradually in treated bulls. There was some improvement in semen characteristics of some of the bulls at 10 weeks post-chemotherapy with Novidium. However, all bulls infected with T. vivax or T. congolense irrespective of Novidium chemotherapy still had poor semen characteristics manifested by all or some of the following: decreased volume of semen, oligospermia, azoospermia and elevated incidence of spermatozoa morphological abnormalities. They were thus unsuitable for breeding.
AuthorsV O Sekoni, C Njoku, D Saror, A Sannusi, B Oyejola, J Kumi-Diaka
JournalThe British veterinary journal (Br Vet J) 1990 Jul-Aug Vol. 146 Issue 4 Pg. 368-73 ISSN: 0007-1935 [Print] England
PMID2397378 (Publication Type: Journal Article)
Chemical References
  • Ethidium
Topics
  • Animals
  • Cattle
  • Ejaculation (drug effects)
  • Ethidium (pharmacology, therapeutic use)
  • Male
  • Semen (drug effects)
  • Trypanosoma congolense
  • Trypanosomiasis, Bovine (drug therapy, physiopathology)

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