Interactions between the sympathetic nervous system and angiotensin system in renovascular hypertension.

Abstract

Renal artery stenosis especially that due to atherosclerotic peripheral vascular disease is increasing in the population. The role of the renin angiotensin aldosterone system in the pathogenesis of renovascular hypertension is widely accepted. There is increasing recognition of the role of the sympathetic nervous system, from both afferent and efferent signaling pathways, as a contributor to development of hypertension. In this review we briefly summarize the experimental evidence for the respective roles of the renin angiotensin aldosterone system and the sympathetic nervous system as well as their interaction in renovascular hypertension.

• Authors: Nishigandha Pradhan, Noreen F Rossi
• Journal: Current hypertension reviews (Curr Hypertens Rev) Vol. 9 Issue 2 Pg. 121-9 (May 2013) ISSN: 1875-6506 [Electronic] United Arab Emirates
• PMID: 23971694 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review)

Topics

• Animals
• Humans
• Hypertension, Renovascular (physiopathology)
• Kidney (innervation, physiopathology)
• Renin-Angiotensin System (physiology)
• Sympathetic Nervous System (physiopathology)