Abstract | OBJECTIVES: The aims of this study were to assess expressions of the DNA damage response (DDR)-related proteins and to investigate their clinical significances in gastric carcinoma. METHODS: RESULTS: ATM loss, Chk2 loss, and p53 positivity were observed in 21.8, 14.1, and 36.1% of the training set, and in 17.3, 12.2, and 35.8% of the validation set, respectively. In the training set, the aberrant expressions of ATM, Chk2, or p53 were significantly associated with an advanced TNM stage and poor disease-specific survival. This association was verified in the validation set. Chk2 positivity and p53 negativity were significantly related to a prolonged disease-specific survival. Also, patients with nonaberrant expressional levels of all 3 DDR-related proteins had a more favorable outcome than others. Multivariate analyses showed that Chk2 loss and at least 1 aberrant DDR-related protein remained as independent prognostic factors of poor disease-specific survival. CONCLUSIONS: This study elucidated the prognostic implications of DDR-related proteins, and suggests that their aberrant expressions play critical roles in the development and progression of gastric cancer.
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Authors | Hee Eun Lee, Nayoung Han, Min A Kim, Hye Seung Lee, Han-Kwang Yang, Byung Lan Lee, Woo Ho Kim |
Journal | Pathobiology : journal of immunopathology, molecular and cellular biology
(Pathobiology)
Vol. 81
Issue 1
Pg. 25-35
( 2014)
ISSN: 1423-0291 [Electronic] Switzerland |
PMID | 23969480
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
- Biomarkers, Tumor
- TP53 protein, human
- Tumor Suppressor Protein p53
- Checkpoint Kinase 2
- ATM protein, human
- Ataxia Telangiectasia Mutated Proteins
- CHEK2 protein, human
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Topics |
- Adenocarcinoma
(metabolism, mortality, pathology)
- Adult
- Aged
- Ataxia Telangiectasia Mutated Proteins
(analysis, biosynthesis)
- Biomarkers, Tumor
(analysis)
- Checkpoint Kinase 2
(analysis, biosynthesis)
- DNA Damage
- Female
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Proportional Hazards Models
- Stomach Neoplasms
(metabolism, mortality, pathology)
- Tissue Array Analysis
- Tumor Suppressor Protein p53
(analysis, biosynthesis)
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