[The potentiating action of artificial immunodeficiency on the development of amyloidosis in plague in great gerbils].

Abstract

Cyclophosphamide injection causes amyloidosis development in the spleen of great gerbils both intact and plague-infected after immunization. The amyloid deposits are observed irrespective of acquired antiplague resistance level. Alterations observed may be considered as acquired (secondary) AA-amyloidosis. Results indicate the significance of immunodepression in amyloidogenesis and a possibility to use the cyclophosphamide-treated great gerbils as a convenient experimental model of amyloidosis.

• Authors: S Iu Zadumina, I V Isupov
• Journal: Arkhiv patologii (Arkh Patol) Vol. 52 Issue 5 Pg. 46-50 ( 1990) ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: Potentsiruiushchee deĭstvie iskusstvennogo immunodefitsita na razvitie amiloidoza pri chume u bol'shikh peschanok.
• PMID: 2396918 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cyclophosphamide

Topics

• Amyloidosis (etiology, immunology, pathology)
• Animals
• Cyclophosphamide (administration & dosage)
• Dose-Response Relationship, Drug
• Gerbillinae
• Immunization
• Immunologic Deficiency Syndromes (chemically induced, complications, immunology, pathology)
• Lymph Nodes (pathology)
• Plague (complications, immunology, pathology)
• Spleen (pathology)
• Time Factors
• Virulence
• Yersinia pestis (immunology, pathogenicity)