Comparison of plasma, liver, and skeletal muscle carnitine concentrations in cats with idiopathic hepatic lipidosis and in healthy cats.

Abstract

Concentrations of total, free, and esterified carnitine were determined in plasma, liver, and skeletal muscle from cats with idiopathic hepatic lipidosis and compared with values from healthy cats. The mean concentrations of plasma, liver, and skeletal muscle total carnitine; plasma and skeletal muscle free carnitine; and plasma and liver esterified carnitine were greater (P less than 0.05) in cats with idiopathic hepatic lipidosis than in control cats. The mean for the ratio of free/total carnitine in plasma and liver was lower (P less than 0.05) in cats with idiopathic hepatic lipidosis than in control cats. These data suggest that carnitine deficiency does not contribute to the pathogenesis of feline idiopathic hepatic lipidosis.

• Authors: G Jacobs, L Cornelius, B Keene, P Rakich, A Shug
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 51 Issue 9 Pg. 1349-51 (Sep 1990) ISSN: 0002-9645 [Print] United States
• PMID: 2396782 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carnitine

Topics

• Animals
• Carnitine (analysis, blood)
• Cat Diseases
• Cats
• Female
• Lipidoses (blood, veterinary)
• Liver (analysis)
• Liver Diseases (blood, veterinary)
• Male
• Muscles (analysis)
• Muscular Diseases (blood, veterinary)