Bullous mycosis fungoides: report of a case complicated by Kaposi's varicelliform eruption.

Abstract

Vesiculobullous eruptions in mycosis fungoides (MF) are extremely rare. Here, we report a case of a 62-year-old woman presenting with erythematous patches and plaques of 2 years in duration, who had recently developed vesicles on erythematous MF plaques. Histopathological examination showed intra-subepidermal blisters, and infiltration of the epidermis by atypical lymphoid cells, forming Pautrier's microabscesses. Negative immunofluorescence excluded autoimmune blistering diseases. Immunohistochemistry revealed a CD4⁺ T-cell phenotype and gene rearrangement study confirmed a clonal T-cell proliferation. Kaposi's varicelliform eruption (KVE) developed in the patient 1 week after initiation of systemic corticosteroids and immunotherapy. Cluster of vesicles and erosions arising on the pre-existing plaque and a positive immunofluorescence test for Herpes simplex virus and histopathological examination confirmed the diagnosis of cutaneous herpes infection. This is the first case report on bullous MF complicated by KVE in the published work.

• Authors: Xiu-Lian Xu, Ying-Xue Huang, Lin Lin, Meng-Li Zhang, Yi-Qun Jiang, Jian-Fang Sun
• Journal: The Journal of dermatology (J Dermatol) Vol. 40 Issue 10 Pg. 844-7 (Oct 2013) ISSN: 1346-8138 [Electronic] England
• PMID: 23961851 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2013 Japanese Dermatological Association.

Topics

• Female
• Humans
• Kaposi Varicelliform Eruption (complications, pathology)
• Middle Aged
• Mycosis Fungoides (complications, pathology)
• Skin (pathology)