Abstract | BACKGROUND: METHODS: Using cross-sectional data from 766 fasting 12- to 19-year-olds in the 2003-2008 NHANES, we examined associations of phthalate metabolites with continuous and categorical measures of homeostatic model assessment of insulin resistance (HOMA-IR). RESULTS: Controlling for demographic and behavioral factors, diet, continuous age, BMI category, and urinary creatinine, for each log (roughly threefold) increase in DEHP metabolites, a 0.27 increase (95% confidence interval 0.14-0.40; P < .001) in HOMA-IR was identified. Compared with the first tertile of DEHP metabolite in the study population (14.5% insulin resistant), the third tertile had 21.6% prevalence (95% confidence interval 17.2%-26.0%; P = .02). Associations persisted despite controlling for bisphenol A, another endocrine-disrupting chemical commonly found in foods, and HOMA-IR and insulin resistance were not significantly associated with metabolites of lower molecular weight phthalates commonly found in cosmetics and other personal care products. CONCLUSIONS: Urinary DEHP concentrations were associated with increased insulin resistance in this cross-sectional study of adolescents. This study cannot rule out the possibility that insulin-resistant children ingest food with higher phthalate content, or that insulin-resistant children excrete more DEHP.
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Authors | Leonardo Trasande, Adam J Spanier, Sheela Sathyanarayana, Teresa M Attina, Jan Blustein |
Journal | Pediatrics
(Pediatrics)
Vol. 132
Issue 3
Pg. e646-55
(Sep 2013)
ISSN: 1098-4275 [Electronic] United States |
PMID | 23958772
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Environmental Pollutants
- Phthalic Acids
- Diethylhexyl Phthalate
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Topics |
- Adolescent
- Child
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(chemically induced, urine)
- Diethylhexyl Phthalate
(toxicity, urine)
- Environmental Pollutants
(toxicity, urine)
- Female
- Humans
- Insulin Resistance
(physiology)
- Male
- Nutrition Surveys
- Phthalic Acids
(toxicity, urine)
- Risk Factors
- Socioeconomic Factors
- Young Adult
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