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[Occurrence of subdural hematoma closely associated with danazol administration in a patient with refractory ITP].

Abstract
We reported a 34-year-old female patient with refractory idiopathic thrombocytopenic purpura (ITP) in whom a subacute subdural hematoma occurred without any preceding trauma during danazol administration which resulted in a marked decrease of plasma fibrinogen level. It is strongly suggested that danazol should be very carefully administered in ITP patients with serious bleeding tendency.
AuthorsK Shinmyozu, T Okadome, Y Maruyama, I Maruyama, M Osame, M Tara
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 31 Issue 5 Pg. 674-5 (May 1990) ISSN: 0485-1439 [Print] Japan
PMID2395216 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Pregnadienes
  • Protein C
  • Antithrombin III
  • Fibrinogen
  • Danazol
Topics
  • Adult
  • Antithrombin III (analysis)
  • Danazol (adverse effects)
  • Female
  • Fibrinogen (analysis)
  • Hematoma, Subdural (chemically induced)
  • Humans
  • Pregnadienes (adverse effects)
  • Protein C (analysis)
  • Purpura, Thrombocytopenic (blood, drug therapy)

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