Abstract | OBJECTIVES: METHODS: This study used a segmental defect rat model contaminated with Staphylococcus aureus and treated with clinically relevant local antibiotic doses, delivered by gel or beads. In the gel group, 1 mL of gel containing gentamicin and vancomycin was spread throughout the wound. In the bead group, four 3-mm beads containing tobramycin and vancomycin were placed in the wound, 2 in the defect and 2 in the adjacent tissue envelope, there was also a control group that received no antibiotic treatment. After 14 days, bone and hardware was harvested for separate microbiological analysis. RESULTS: There was a significantly lower infection rate in groups treated with antibiotics delivered by gel compared with those treated with either antibiotic beads or no antibiotics at all (P < 0.001). Quantitative cultures also demonstrate significantly less bacteria in the wounds treated with the gel than in the control or bead groups (P ≤ 0.004). CONCLUSIONS:
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Authors | Jowan G Penn-Barwell, Clinton K Murray, Joseph C Wenke |
Journal | Journal of orthopaedic trauma
(J Orthop Trauma)
Vol. 28
Issue 6
Pg. 370-5
(Jun 2014)
ISSN: 1531-2291 [Electronic] United States |
PMID | 23948961
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Drug Carriers
- Gels
- Gentamicins
- Vancomycin
- Polymethyl Methacrylate
- Tobramycin
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Topics |
- Absorbable Implants
- Administration, Topical
- Animals
- Anti-Bacterial Agents
(administration & dosage)
- Disease Models, Animal
- Drug Carriers
(administration & dosage)
- Femoral Fractures
(complications, surgery)
- Fractures, Open
(complications, surgery)
- Gels
- Gentamicins
(administration & dosage)
- Polymethyl Methacrylate
- Rats
- Staphylococcal Infections
- Staphylococcus aureus
- Surgical Wound Infection
(etiology, microbiology, prevention & control)
- Tobramycin
(administration & dosage)
- Vancomycin
(administration & dosage)
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