Abstract |
Extracellular matrix metalloproteinase inducer (CD147) is a transmembrane glycoprotein involved in the regulation of matrix metalloproteinases ( MMPs). The study investigated CD147 and MMP-2 expression in epidermis of cutaneous squamous lesions. CD147 and MMP-2 expressions were evaluated immunohistochemically in 44 specimens: 18 actinic keratoses (AK), 6 squamous cell carcinomas in situ (SCCIS), 13 squamous cell carcinomas (SCC; peritumoral and invasive portions assessed), and 7 normal skins. Patterns of expression were assessed, with MMP-2 in nuclei (MMP-2n) and cytoplasm (MMP-2c) evaluated separately. The expression of each marker was quantified using a calculated immunohistochemical/histologic score (H-score). Correlations were analyzed for the marker H-scores in each study group. Associations between H-scores and histopathologic parameters were also evaluated. CD147 H-score was the highest in SCC (invasive islands), followed by AK, SCCIS, and control specimens, respectively. MMP-2n and MMP-2c H-scores were the highest in AK, followed by SCCIS, SCC, and control specimens, respectively. MMP-2c and MMP-2n H-scores were significantly higher in peritumoral epidermis than in invasive islands of SCC. MMP-2c and CD147 H-scores were positively correlated in the peritumoral SCCs. CD147 H-score was positively correlated with tumor differentiation in SCC. The findings suggest that overexpression of CD147 plays a role in the development of SCC.
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Authors | Sebnem Kupana Ayva, Ayse Anil Karabulut, Ayşe Nur Akatli, Pinar Atasoy, Onder Bozdogan |
Journal | Pathology, research and practice
(Pathol Res Pract)
Vol. 209
Issue 10
Pg. 627-34
(Oct 2013)
ISSN: 1618-0631 [Electronic] Germany |
PMID | 23948694
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier GmbH. All rights reserved. |
Chemical References |
- BSG protein, human
- Biomarkers, Tumor
- Basigin
- Matrix Metalloproteinase 2
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Basigin
(analysis, biosynthesis)
- Biomarkers, Tumor
(analysis)
- Carcinoma, Squamous Cell
(metabolism)
- Epithelial Cells
(metabolism)
- Extracellular Space
(enzymology)
- Female
- Humans
- Immunohistochemistry
- Keratosis, Actinic
(metabolism)
- Male
- Matrix Metalloproteinase 2
(analysis, biosynthesis)
- Middle Aged
- Precancerous Conditions
(metabolism)
- Skin Neoplasms
(metabolism)
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