adverse events and efficacy of treatment.
STUDIES: randomized controlled trials.
RESULTS: Five randomized controlled trials with a total of 639 patients (326 adjunctive
aripiprazole, 313 adjunctive placebo) met the inclusion criteria. Adjunctive
aripiprazole was associated with a 79.11% (125/158)
prolactin level normalization rate. Meta-analysis of
insomnia,
headache, sedation,
psychiatric disorder, extrapyramidal symptom, dry mouth, and
fatigue showed no significant differences in the adjunctive
aripiprazole treatment group compared with the placebo group (risk difference (Mantel-Haenszel, random or fixed) -0.05 to 0.04 (95% confidence interval -0.13 to 0.16); I(2) =0% to 68%, P=0.20 to 0.70). However, sedation,
insomnia, and
headache were more frequent when the adjunctive
aripiprazole dose was higher than 15 mg/day. Meta-analysis of the
prolactin level normalization indicated adjunctive
aripiprazole was superior to placebo (risk difference (Mantel-Haenszel, random) 0.76 (95% confidence interval 0.67 to 0.85); I(2) =43%, P<0.00001). The subgroup analysis confirmed that the subjects who received adjunctive
aripiprazole 5 mg/day showed a degree of
prolactin normalization similar to that of all participants. No significant differences between groups in discontinuation and improvements of psychiatric symptoms.
CONCLUSION: