Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity.

Abstract

Embryo attachment and implantation is critical to successful reproduction of all eutherian mammals, including humans; a better understanding of these processes could lead to improved infertility treatments and novel contraceptive methods. Experience with assisted reproduction, especially oocyte donation cycles, has established that despite the diverse set of hormones produced by the ovary in a cycle-dependent fashion, the sequential actions of only two of them, oestrogen and progesterone, are sufficient to prepare a highly receptive endometrium in humans. Further investigation on the endometrial actions of these two hormones is currently providing significant insight into the implantation process in women, strongly suggesting that an abnormal response to progesterone underlies infertility in some patients.

• Authors: Steven L Young
• Journal: Reproductive biomedicine online (Reprod Biomed Online) Vol. 27 Issue 5 Pg. 497-505 (Nov 2013) ISSN: 1472-6491 [Electronic] Netherlands
• PMID: 23933037 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2013 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Estrogens
• Progesterone

Topics

• Embryo Implantation (drug effects, physiology)
• Endometriosis (metabolism)
• Endometrium (drug effects, metabolism)
• Estrogens (metabolism, pharmacology, physiology)
• Female
• Humans
• Infertility, Female (physiopathology)
• Models, Biological
• Progesterone (metabolism, pharmacology, physiology)