Oral temafloxacin versus vancomycin for therapy of experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.

Abstract

We compared oral temafloxacin, a new fluoroquinolone agent, with vancomycin, each with and without rifampin, in the therapy of rats with aortic valve endocarditis caused by a clinical isolate of methicillin-resistant Staphylococcus aureus. The temafloxacin, vancomycin, and rifampin MICs and MBCs were 0.78 and 1.56, 1.56 and 3.13, and less than 0.024 and 0.78 microgram/ml, respectively. The animals were classified into the following six treatment groups: vancomycin (60 mg/kg) +/- rifampin (6 mg/kg) each intramuscularly every 12 h for 5 days; temafloxacin (100 mg/kg) orally +/- rifampin (6 mg/kg) intramuscularly every 12 h for 5 days; rifampin (6 mg/kg) intramuscularly every 12 h for 5 days; and untreated controls. All regimens with either vancomycin or temafloxacin resulted in improved survival over controls, but only temafloxacin regimens resulted in a significant reduction in bacterial counts in vegetations. These data support further investigation of the efficacy of temafloxacin in treating serious infections caused by methicillin-resistant S. aureus.

• Authors: M T Hessen, P G Pitsakis, D Kaye
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 34 Issue 6 Pg. 1143-5 (Jun 1990) ISSN: 0066-4804 [Print] United States
• PMID: 2393273 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 4-Quinolones
• Anti-Infective Agents
• Fluoroquinolones
• Quinolones
• temafloxacin
• Vancomycin
• Methicillin
• Rifampin

Topics

• 4-Quinolones
• Administration, Oral
• Animals
• Anti-Infective Agents (blood, pharmacokinetics, therapeutic use)
• Drug Therapy, Combination (therapeutic use)
• Endocarditis, Bacterial (drug therapy)
• Fluoroquinolones
• Male
• Methicillin (pharmacology)
• Microbial Sensitivity Tests
• Penicillin Resistance
• Quinolones
• Rats
• Rats, Inbred Strains
• Rifampin (therapeutic use)
• Staphylococcal Infections (drug therapy)
• Vancomycin (blood, pharmacokinetics, therapeutic use)