Abstract |
The study was designed to compare the efficacy of cetylpyridinium chloride ( CPC) and sodium chloride (NaCl) decontamination method with N-acetyl L-Cystine (NALC) and sodium hydroxide (NaOH) decontamination (the reference method) method for the recovery of Mycobacterium tuberculosis (MTB) from clinically suspected cases of pulmonary tuberculosis. To evaluate CPC-NaCl and NALC-NaOH decontamination methods, sputum specimens (n = 796) were studied (culturing on Löwenstein-Jensen medium), and the performances were compared. The CPC-NaCl decontamination method demonstrated a sensitivity, specificity, negative predictive value, and positive predictive value of 97.99%, 87.53%, 70.19%, and 99.32%, respectively, when compared to NALC-NaOH decontamination method. In summary, CPC-NaCl decontamination method effectively detected significantly higher number of MTB cases (n = 208) than NALC-NaOH decontamination method (n = 149) particularly in sputum with scanty bacilli and smear-negative cases, indicating the potential of CPC-NaCl decontamination method to preserve paucibacillary cases more efficient than NALC-NaOH decontamination method.
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Authors | Pottathil Shinu, Varsha Singh, Anroop Nair, Priya Mehrishi, Sonia Mehta, Ekta Joshi |
Journal | Diagnostic microbiology and infectious disease
(Diagn Microbiol Infect Dis)
Vol. 77
Issue 2
Pg. 150-7
(Oct 2013)
ISSN: 1879-0070 [Electronic] United States |
PMID | 23928270
(Publication Type: Journal Article)
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Copyright | © 2013. |
Chemical References |
- Sodium Chloride
- Cystine
- Cetylpyridinium
- N-monoacetylcystine
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Topics |
- Adult
- Bacteriological Techniques
(methods)
- Cetylpyridinium
(chemistry)
- Cystine
(analogs & derivatives, chemistry)
- Female
- Humans
- Male
- Microscopy
- Mycobacterium tuberculosis
(isolation & purification)
- Reproducibility of Results
- Sensitivity and Specificity
- Sodium Chloride
(chemistry)
- Sputum
(microbiology)
- Tuberculosis, Pulmonary
(diagnosis, microbiology)
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