Abstract |
Toxoplasma gondii is an intracellular parasite that has evolved to actively control its invaded host cells. Toxoplasma triggers then actively regulates host innate interleukin-12 (IL-12) and interferon-γ (IFN-γ) responses that elicit T cell control of infection. A live, nonreplicating avirulent uracil auxotroph vaccine strain (cps) of Toxoplasma triggers novel innate immune responses that stimulate amplified CD8(+) T cell responses and life-long immunity in vaccinated mice. Here, we review recent reports showing that intratumoral treatment with cps activated immune-mediated regression of established solid tumors in mice. We speculate that a better understanding of host-parasite interaction at the molecular level and applying improved genetic models based on Δku80 Toxoplasma strains will stimulate development of highly effective immunotherapeutic cancer vaccine strategies using engineered uracil auxotrophs.
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Authors | Barbara A Fox, Kiah L Sanders, Shan Chen, David J Bzik |
Journal | Trends in parasitology
(Trends Parasitol)
Vol. 29
Issue 9
Pg. 431-7
(Sep 2013)
ISSN: 1471-5007 [Electronic] England |
PMID | 23928100
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Cancer Vaccines
- Protozoan Vaccines
- Vaccines, Attenuated
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Topics |
- Animals
- CD8-Positive T-Lymphocytes
(immunology)
- Cancer Vaccines
(therapeutic use)
- Immunity, Innate
(immunology)
- Mice
- Neoplasms
(therapy)
- Protozoan Vaccines
(therapeutic use)
- Toxoplasma
(immunology)
- Vaccines, Attenuated
(therapeutic use)
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