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Monitoring Doppler patterns and clinical parameters may predict feeding tolerance in intrauterine growth-restricted infants.

AbstractAIM:
To detect predictors of feeding tolerance in intrauterine growth restriction (IUGR) infants with or without brain-sparing effect (BS).
METHODS:
We conducted a case-control study in 70 IUGR infants (35 IUGR with BS, matched for gestational age with 35 IUGR infants with no BS). BS was classified as pulsatility index (PI) ratio [umbilical artery (UAPI) to middle cerebral artery (MCAPI) (U/C ratio)] > 1. Clinical parameters of feeding tolerance - days to achieve full enteral feeding (FEF) - were compared between the IUGR with BS and IUGR without BS infants. Age at the start of minimal enteral feeding (MEF) was analysed.
RESULTS:
Achievement of FEF was significantly shorter in IUGR infants without BS than in IUGR with BS. IUGR with BS started MEF later than IUGR without BS infants. Significant correlation of MEF and FEF with UA PI, U/C ratio and CRIB score was found. Multiple linear regression analysis showed significant correlations with CRIB score and caffeine administration (MEF only), and sepsis (FEF only) and U/C ratio (for both).
CONCLUSION:
Impaired gut function can be early detected by monitoring Doppler patterns and clinical parameters.
AuthorsValentina Bozzetti, Giuseppe Paterlini, Diego Gazzolo, Frank Van Bel, Gerard H A Visser, Nadia Roncaglia, Paolo E Tagliabue
JournalActa paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 102 Issue 11 Pg. e519-23 (Nov 2013) ISSN: 1651-2227 [Electronic] Norway
PMID23927730 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright©2013 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Topics
  • Case-Control Studies
  • Enteral Nutrition (statistics & numerical data)
  • Female
  • Fetal Growth Retardation (diagnostic imaging, physiopathology)
  • Gastrointestinal Tract (physiopathology)
  • Hemodynamics
  • Humans
  • Infant, Newborn
  • Linear Models
  • Male
  • Predictive Value of Tests
  • Pregnancy
  • Ultrasonography, Doppler
  • Ultrasonography, Prenatal

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