Abstract | OBJECTIVES: Psoralea corylifolia is a plant widely used in traditional Chinese medicine, e.g. for its chemopreventive effect. To identify active substances responsible for this effect, we investigated pharmacological effects of 11 compounds isolated from the seeds of this plant (newly described substances: 7, 2', 4'-trihydroxy-3-arylcoumarin and psoracoumestan). METHODS: KEY FINDINGS: CONCLUSIONS: Distinct compounds isolated from P. corylifolia showed a high potential to influence cellular pathways, e.g. by inhibition of protein kinases that may be interesting for pharmacological purposes.
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Authors | Christian Limper, Yao Wang, Sven Ruhl, Zhiqiang Wang, Yijia Lou, Frank Totzke, Michael H G Kubbutat, Yvonni Chovolou, Peter Proksch, Wim Wätjen |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 65
Issue 9
Pg. 1393-408
(Sep 2013)
ISSN: 2042-7158 [Electronic] England |
PMID | 23927478
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Royal Pharmaceutical Society. |
Chemical References |
- Antineoplastic Agents, Phytogenic
- Plant Extracts
- Protein Kinase Inhibitors
- Chalcone
- xanthoangelol
- ErbB Receptors
- Mitogen-Activated Protein Kinases
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(isolation & purification, pharmacology, therapeutic use)
- Apoptosis
(drug effects)
- Chalcone
(analogs & derivatives, isolation & purification, pharmacology, therapeutic use)
- ErbB Receptors
(antagonists & inhibitors)
- HCT116 Cells
- Humans
- Inhibitory Concentration 50
- Mitogen-Activated Protein Kinases
(antagonists & inhibitors)
- Neoplasms
(drug therapy, metabolism)
- Phytotherapy
- Plant Extracts
(chemistry, pharmacology, therapeutic use)
- Protein Kinase Inhibitors
(isolation & purification, pharmacology, therapeutic use)
- Psoralea
(chemistry)
- Rats
- Seeds
(chemistry)
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