Abstract | BACKGROUND: Snail transcription factor and Maspin tumor suppressor serpin are involved in the regulation of progression, invasion and metastasis of many human malignancies. However, there is very limited data in the literature about their role in prostatic adenocarcinoma. The present study was designed to investigate Snail and Maspin expression, their interrelationship and their relationship to different clinicopathologic variables in clinically detectable prostatic adenocarcinoma. MATERIAL AND METHODS: RESULTS: Snail protein expression was detected in 53.8% of prostatic adenocarcinomas versus none of BPH cases (p = < 0.001). A significant positive correlation of Snail expression to cancer grade (p = 0.015), lymph node metastasis (p = 0.026) and pTNM stage (p = 0.036). Maspin expression was detected in 36.6% of prostatic adenocarcinomas versus 93.3% of BPH cases (p = < 0.001). A significant negative correlation of Maspin expression to cancer grade (p = 0.007) and lymphovascular invasion (p = 0.017). Also detected was a significant negative relationship between Snail and Maspin expression in cancer cases under investigation (p = 0.002). CONCLUSION: Snail immunohistochemical expression can be promising as a potential prognostic biomarker in prostatic adenocarcinoma since it was significantly associated with clinicopathologic variables of progressive disease. A potential role for Snail in regulating Maspin expression is suggested based on the finding of negative association between Snail and Maspin expression in prostatic adenocarcinoma.
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Authors | Ashraf Ishak Fawzy, Mariana Fathy Gayyed, Gamal Abd Elhamid Elsaghir, Mohamed Salah Elbadry |
Journal | International journal of clinical and experimental pathology
(Int J Clin Exp Pathol)
Vol. 6
Issue 8
Pg. 1558-66
( 2013)
ISSN: 1936-2625 [Electronic] United States |
PMID | 23923074
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- SERPIN-B5
- Serpins
- Snail Family Transcription Factors
- Transcription Factors
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Aged
- Biomarkers, Tumor
(analysis)
- Egypt
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Prostatic Hyperplasia
(metabolism, pathology)
- Prostatic Neoplasms
(metabolism, pathology)
- Serpins
(analysis, biosynthesis)
- Snail Family Transcription Factors
- Transcription Factors
(analysis, biosynthesis)
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