Abstract | BACKGROUND: The aim of our study was to investigate the association of C4.4A expression in breast tumors with both patients' clinicopathological characteristics and outcomes in order to clarify the significance of C4.4A in breast cancer. METHODS: RESULTS: Multivariate analysis showed that HER2 positivity was the only independent predictive factor for C4.4A expression (odds ratio 5.31, 95 % confidence interval 2.04-15.72; P < 0.001). Univariate prognostic analysis of the relationship between C4.4A and disease-free survival showed that survival of patients with C4.4A-positive tumors was longer than that of patients with C4.4A-negative tumors in the HER2-positive subset (P = 0.004) while there was no significant difference in patient outcome according to C4.4A status for total patients (median observation period 37 months, range 1-92 months; P = 0.223). CONCLUSIONS: We established a positive relationship between C4.4A and HER2 status, suggesting that C4.4A expression may be a prognostic factor for HER2-positive breast cancer patients.
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Authors | Tomohiro Miyake, Takashi Ito, Ayako Yanai, Natsuko Inoue, Yoshimasa Miyagawa, Keiko Murase, Michiko Imamura, Shigetoshi Ichii, Yuichi Takatsuka, Tomoyuki Nishizaki, Seiichi Hirota, Masahisa Ohtsuka, Hirofumi Yamamoto, Shinzaburo Noguchi, Yasuo Miyoshi |
Journal | Breast cancer (Tokyo, Japan)
(Breast Cancer)
Vol. 22
Issue 4
Pg. 366-73
(Jul 2015)
ISSN: 1880-4233 [Electronic] Japan |
PMID | 23918676
(Publication Type: Clinical Study, Journal Article)
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Chemical References |
- Cell Adhesion Molecules
- GPI-Linked Proteins
- LYPD3 protein, human
- ERBB2 protein, human
- Receptor, ErbB-2
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Topics |
- Breast Neoplasms
(metabolism, mortality, pathology, surgery, therapy)
- Cell Adhesion Molecules
(metabolism)
- Disease-Free Survival
- Female
- GPI-Linked Proteins
(metabolism)
- Humans
- Mastectomy
- Neoplasm Recurrence, Local
- Prognosis
- Receptor, ErbB-2
(metabolism)
- Treatment Outcome
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